Gamma Delta chapter started out as a local sorority on South's campus called Alpha Pi in April 1966. National Panhellenic Council rules did not allow a national sorority to have a colony if the school was unaccredited. Because the University of South Alabama had only been open about a year, it was not yet an accredited school. Alpha Pi was then started as a local chapter. With the assistance of Mobile AOII alumnae, Gamma Delta was installed with 25 members by President Carolyn Huey Harris, Lambda Sigma (University of Georgia, Athens, Georgia). Gamma Delta was chartered at the University of South Alabama on March 29, 1969 as Alpha Omicron Pi's 107th chapter.
The chapter's many campus and community activities have garnered USA's Most Campus Involvement Trophy, and first place in many efforts such as blood and food drives. Chapter members have served as Homecoming queens and court members and achieved Panhellenic's highest GPA.
AOII recognitions have included the JWH Cup in 1991 and Distinguished Service Awards in 1987, 1989, 1991, and 1995. The JWH Cup honors one collegiate chapter with the most outstanding service to college or community and fulfillment of obligations to Alpha Omicron Pi.